ROY PATTERSON, M.D., F.A.C.P.; MICHAEL SCHATZ, M.D.
Readministration of a diagnostic or therapeutic agent to a patient with a history of an adverse reaction to that agent may have grave medical and medicolegal consequences. Nonetheless, it is in the patient's best interest under certain circumstances to do this when the potential value of the agent exceeds the potential risk of readministration of the agent. An example of current importance is the administration of a radiographic contrast medium. Reaction to radiographic contrast media is a special case among immediate-type drug reactions because no adequate substitutes for them exist, such reactions have not been shown to be IgE mediated,
PATTERSON R, SCHATZ M. Administration of Radiographic Contrast Medium After a Prior Adverse Reaction. Ann Intern Med. ;83:277. doi: 10.7326/0003-4819-83-2-277
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Published: Ann Intern Med. 1975;83(2):277.
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