MICHAEL C. RUDDY, M.D.
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To the editor: I read with great interest the recent study by Thompson, Johnson, Maddrey, et al (Ann Intern Med 82:175-180, 1975) of the treatment of delirium tremens by diazepam or paraldehyde. This study clearly shows the superior efficacy and safety of parenteral diazepam as opposed to rectal paraldehyde in the initial management of these patients.
After induction of a calm state the patients required an average of 155 mg of diazepam and only 67 ml of paraldehyde. Although the specific data are not included in the article, the frequency of administered doses of diazepam required for maintenance appears to
RUDDY MC. Diazepam or Paraldehyde for Delirium Tremens. Ann Intern Med. ;83:279. doi: 10.7326/0003-4819-83-2-279_2
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Published: Ann Intern Med. 1975;83(2):279.
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