ROBERT C. BARGER, M.S., R.PH.; JOHN F. MITCHELL, PHARM.D.
To the editor: In their recent paper, Littman and Pine (1) stated that "anticholinergics should not be combined with antacids because absorption of the anticholinergic is reduced. . . ." This remark was not referenced, which led to our investigating the clinical significance of this drug interaction.
Dotevall and Walan (2) studied the effect of 1-hyoscyamine on duration of antacid action. Antacid administration alone produced a duration of pH ≥ 3 for 28.9 ± 6.1 minutes, while concomitant dosing with the anticholinergic increased this pH limit to 71.1 ± 12.0 minutes (P < 0.01). Morrissey and associates (3), using a
BARGER RC, MITCHELL JF. Antacids and Anticholinergics. Ann Intern Med. ;83:280–281. doi: 10.7326/0003-4819-83-2-280_2
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Published: Ann Intern Med. 1975;83(2):280-281.
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