ROBERT E. SLAYTON, M.D.; CHARLES PERLIA, M.D.; JOHN SHOWEL, M.D.; THOMAS HOELTGEN, M.D.; JANET WOLTER, M.D.
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To the editor: We take strong issue with a recent letter from A. W. Hopefl (Ann Intern Med 82:722, 1975) suggesting that mithramycin be reserved for the hypercalcemic patient who has not responded to "other more benign therapy" and used only by those experienced in chemotherapy. We have found mithramycin more reliable, yet no more toxic than other hypercalcemic agents, and strongly encourage its use early in the treatment of hypercalcemia. It is quite clear that the risks of hypercalcemia are greater than the risks of mithramycin if attention is paid to dose and frequency of administration.
SLAYTON RE, PERLIA C, SHOWEL J, HOELTGEN T, WOLTER J. Mithramycin for Hypercalcemia. Ann Intern Med. ;83:288. doi: 10.7326/0003-4819-83-2-288_1
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Published: Ann Intern Med. 1975;83(2):288.
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