WILLIAM O. DOBBINS III, M.D.
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To the editor: I read with considerable interest the paper by Linsk, Khoory, and Meyers (Ann Intern Med 82:659-662, 1975). I agree with the authors that the electron microscopic findings of intranuclear and intracytoplasmic linear "crystalloid" structures in the mature neutrophils of the two subjects are unique in that such an observation has not been previously reported. However, this finding may not be characteristic of the disorder that they describe. We observed similar intracytoplasmic and intranuclear filaments in polymorphonuclear leukocytes (Figure 1) found in the colonic specimen of a patient who had total colectomy for treatment of Crohn's disease. There
DOBBINS WO. Myeloid, Erythroid, and Immune System Defects in a Family. Ann Intern Med. ;83:431–432. doi: 10.7326/0003-4819-83-3-431_2
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Published: Ann Intern Med. 1975;83(3):431-432.
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