ARTHUR J. MATAS, M.D.; RICHARD L. SIMMONS, M.D.; FREDERICK C. GOETZ, M.D.; CARL M. KJELLSTRAND, M.D.; JOHN S. NAJARIAN, M.D.
Serum creatinine elevation in a stable transplant recipient suggests rejection of the transplant and requires further evaluation and management. Eighty-seven patients with juvenile onset diabetes mellitus have received kidney transplants at the University of Minnesota between January 1968 and August 1974. In this patient-population, we have frequently observed significant elevations in serum creatinine levels (> 25%) in association with hyperglycemia. Correction of the hyperglycemia resulted in return of serum creatinine to normal levels without the use of antirejection therapy. Differentiation of these cases from true rejection cases is important in order to prevent unnecessary toxicity due to the therapy used
MATAS AJ, SIMMONS RL, GOETZ FC, KJELLSTRAND CM, NAJARIAN JS. Increased Serum Creatinine Resulting from Hyperglycemia, Mimicking Transplant Rejection. Ann Intern Med. ;83:519–520. doi: 10.7326/0003-4819-83-4-519
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Published: Ann Intern Med. 1975;83(4):519-520.
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