PETER H. WIERNIK, M.D.
To the editor: Dr. Kremer states in his review of the usefulness of cytarabine (Ann Intern Med 82:684-688, 1975) that "three different regimens involving combinations of cytarabine with other active agents have consistently produced a complete remission rate greater than 50% in adults" (with acute myeloblastic leukemia), and he cites the work of Clarkson (1), Crowther and associates (2), and Whitecar and colleagues (3). Actually, the complete remission rates in the studies cited are somewhat lower than Dr. Kremer indicates. The latest evaluation of the Clarkson study shows a complete remission rate of 56% in 88 previously untreated patients with
WIERNIK PH. Cytarabine: Therapeutic Trials and Editorial Standards. Ann Intern Med. ;83:578. doi: 10.7326/0003-4819-83-4-578
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Published: Ann Intern Med. 1975;83(4):578.
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