ROBERT VAN HOOK, M.D.; ALEXANDER G. VANDEVELDE, M.D.
Gas gangrene developing at the site of intramuscular injection is fulminating and associated with high mortality. We report here a patient who died 36 hours after injection of epinephrine in oil in the buttocks. Clostridial myonecrosis has occurred under similar circumstances since administration of drugs intramuscularly became common practice at the beginning of this century. Touraine (1), reviewing the subject in 1936, mentioned epinephrine as the most frequently offending drug. After World War II additional patients were described by Marshall and Sims (2) and Koons and Boyden (3), who referred to another 30 cases in Brazil.
Our patient, a 64-year-old
VAN HOOK R, VANDEVELDE AG. Gas Gangrene After Intramuscular Injection of Epinephrine: Report of Fatal Case. Ann Intern Med. ;83:669–670. doi: 10.7326/0003-4819-83-5-669
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Published: Ann Intern Med. 1975;83(5):669-670.
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