DONALD E. BUTKUS, M.D., LTC, MC
To the editor: The paper by Fleming and associates in the July issue (Ann Intern Med 83:60-62, 1975) understates the possible role of volume repletion in contributing to the suppression of serum renin levels noted during the early period of potassium repletion in their patient (Figures 1 and 2, p. 61). During the initial period of potassium repletion, although external sodium balance was maintained, a positive balance of over 300 meq of potassium was attained with an increase in body weight of 1 kg.
Potassium depleted states are accompanied by a reciprocal increase in intracellular sodium (1-3). Repletion of the
BUTKUS DE. Renin Suppression. Ann Intern Med. ;83:737. doi: 10.7326/0003-4819-83-5-737_1
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Published: Ann Intern Med. 1975;83(5):737.
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