FREDERICK L. GLAUSER, M.D.; WILLIAM RICHARD SMITH, M.D.; ALEX CALDWELL, M.D.; MELVIN HOSHIKO, M.D.; GEOFFREY S. DOLAN, M.D.; HAROLD BAER, M.D.; NEAL OLSHER, M.D.
Two patients experienced severe nonhemodynamic pulmonary edema following the intravenous injection of 25 and 40 mg/kg of body weight of ethchlorvynol (Placidyl⌖). The pulmonary edema cleared rapidly. Injection of Placidyl (12 to 80 mg/kg of body weight) intravenously into dogs caused acute, severe, nonhemodynamic pulmonary edema (as evidenced by markedly elevated lung weights and microscopic evidence of intra-alveolar edema), hypotension with a relative bradycardia, and a decreased cardiac output. Injection of polyethylene glycol, the vehicle in which ethchlorvynol is diluted, did not reproduce the syndrome.
GLAUSER FL, SMITH WR, CALDWELL A, HOSHIKO M, DOLAN GS, BAER H, et al. Ethchlorvynol (Placidyl⌖)-Induced Pulmonary Edema. Ann Intern Med. ;84:46–48. doi: 10.7326/0003-4819-84-1-46
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Published: Ann Intern Med. 1976;84(1):46-48.
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