BENNETT LORBER, M.D.; CHARLES CUTLER, M.D.; WILLIAM E. BARRY, M.D.
Adverse reactions to the widely used antifungal agent, amphotericin B, are frequent and include fever, chills, nausea, vomiting, phlebitis, azotemia, hypokalemia, and anemia (1, 2). However, it has been stated (2) that allergic reactions are "so rare as to cast doubt on their relation to amphotericin B." We report a case in which a generalized pruritic maculopapular rash and eosinophilia were apparently manifestations of hypersensitivity to amphotericin B.
A 55-year old white man, with a past history of pulmonary tuberculosis was admitted to Temple University Hospital on 12 April 1975 for evaluation of fever and anemia. Three months before admission,
LORBER B, CUTLER C, BARRY WE. Allergic Rash Due to Amphotericin B. Ann Intern Med. ;84:54. doi: 10.7326/0003-4819-84-1-54
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Published: Ann Intern Med. 1976;84(1):54.
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