JACK J. STEIN, M.D.
To the editor: In their recent paper "Combined Propranolol and Digoxin Therapy in Angina Pectoris" (Ann Intern Med 83:449-455, 1975), Crawford and associates, having proved combination therapy effective, leave an important question unanswered, namely, what are the indications for its use.
The patients in their study had apparently never been given a trial of nitrates, although some physicians believe that nitrates are the drugs of choice in stable angina (1), particularly when only one coronary artery is involved (2), and that propranolol is useful as a second-line drug when nitrates fail.
The point to be made is that, in the
STEIN JJ. Propranolol and Digoxin for Angina Pectoris. Ann Intern Med. ;84:99. doi: 10.7326/0003-4819-84-1-99_2
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Published: Ann Intern Med. 1976;84(1):99.
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