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Between 1958, when R. R. Porter opened the modern era of research on immunoglobulin structure, and 1974, when the first three-dimensional models of immunoglobulin molecules became available, the immunoglobulins of man, rabbit, mouse, other mammals, and lower vertebrates were intensively studied. The heterogeneity of immunoglobulins within a species, relating to combining specificity and physiological properties, presented formidable problems. Many laboratories vigorously isolated, chemically characterized, and classified immunoglobulins. Much of this work is summarized in the monograph by an outstanding group of immunochemists whose own work has contributed in a major way to the development and understanding of immunoglobulins.
The Antibody Molecule.. Ann Intern Med. ;84:111. doi: 10.7326/0003-4819-84-1-111_1
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Published: Ann Intern Med. 1976;84(1):111.
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