S. FISCH, M.D., PH.D., F.A.C.P.
To the editor: It is a pity that so much time and excellent effort was expended by Crawford and associates (Ann Intern Med 83:449-455, 1975) in the conception and execution of their work on propranolol, digoxin, and angina pectoris, to have the study nullified by the retention of investigational bias.
Had these investigators followed a double-blind randomized pattern rather than one of fixed sequence in drug administration the conclusions of this otherwise beautiful study would have been unassailable. The problem of digoxin persistence on cross-over could have been eliminated by lengthening each period to allow reasonably for 2 weeks of
FISCH S. Propranolol, Digoxin, and Angina Pectoris. Ann Intern Med. ;84:219–220. doi: 10.7326/0003-4819-84-2-219
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Published: Ann Intern Med. 1976;84(2):219-220.
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