HARVEY J. BERGER; TRAVIS WINSOR, M.D., F.A.C.P.
To the editor: In their recent paper, Shim and Williams (Ann Intern Med 83:208-211, 1975) reported that multiple doses of isoproterenol aerosol did not produce cardiac conduction defects, arrhythmias, or ST-segment changes in asthmatic patients who regularly used isoproterenol. In contrast, we have found that isoproterenol administered in similar therapeutic doses to patients with various conditions results in electrocardiographic changes consistent with myocardial ischemia (1, 2).
Retrospectively, we identified seven patients with bronchial asthma who had developed ST-segment depression during aerosol administration of isoproterenol. Two of these patients evolved subendocardial infarcts with characteristic substernal chest pain and enzyme changes. One
BERGER HJ, WINSOR T. Isoproterenol and Electrocardiographic Findings. Ann Intern Med. ;84:221–222. doi: 10.7326/0003-4819-84-2-221_3
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Published: Ann Intern Med. 1976;84(2):221-222.
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