W. B. LUNDBERG, M.D.; L. R. FARBER, M.D.; E. C. CADMAN, M.D.; R. T. SKEEL, M.D.
Acute leukemia has frequently developed in patients with polycythemia vera. However, its occurrence varies considerably depending on treatment. The occurrence in patients treated with ionizing radiation is higher than that in patients treated with chemotherapy (1) and the "spontaneous" (no leukemogenic exposure) development has been reported only rarely. Because of this discrepancy in the frequency of occurrence, it remains unclear whether acute leukemia is part of the natural history of polycythemia vera, is the consequence of therapy alone, or results from an interaction between these two factors. We treated a man in whom acute leukemia developed after only 4 years
LUNDBERG WB, FARBER LR, CADMAN EC, SKEEL RT. Spontaneous Acute Leukemia in Polycythemia Vera. Ann Intern Med. ;84:294–295. doi: 10.7326/0003-4819-84-3-294
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Published: Ann Intern Med. 1976;84(3):294-295.
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