MICHAEL N. GOTTLIEB, M.D.
To the editor: Matas and associates (1) describe the adverse effect of hyperglycemia on renal function. They could not ascribe the change in serum creatinine reported to an artifact in the method of serum creatinine determination and alternatively proposed that there was reversible physiologic injury to the kidney as a consequence of hyperosmolality. I too have seen this phenomenon but have ascribed this to prerenal azotemia as a consequence of dehydration secondary to osmotic diuresis (2). It would be interesting to note the relative changes in the weights of patients of Matas and colleagues with reversion of glucose and creatinine
GOTTLIEB MN. Hyperglycemia and Renal Function. Ann Intern Med. ;84:339. doi: 10.7326/0003-4819-84-3-339_1
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Published: Ann Intern Med. 1976;84(3):339.
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