WALLACE V. EPSTEIN, M.D., F.A.C.P.; MARTIN A. SHEARN, M.D., F.A.C.P.
To the editor: Two papers (1, 2) and an editorial (3) in the November 1975 issue leave an impression that immunosuppressive drugs offer little more than prednisone in the management of the nephropathy of systemic lupus erythematosus. The reputation of these agents is further impugned by their recorded toxic effects including emergence of infections, alopecia, germ cell suppression, and severe bladder complications.
Analysis of the papers reveals that Hahn, Kantor, and Osterland (1) include only six patients with biopsy-proved diffuse glomerulonephritis in each of the two treatment groups. The remainder of the patients had focal glomerulitis, regarded by most authors
EPSTEIN WV, SHEARN MA. Immunosuppressive Drugs in Lupus Nephritis. Ann Intern Med. ;84:492–493. doi: 10.7326/0003-4819-84-4-492
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Published: Ann Intern Med. 1976;84(4):492-493.
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