ANDREI CALIN, M.D.; JAMES F. FRIES, M.D.
The relation between a specific infective event (shigellosis), a specific disease entity (Reiter's syndrome), and a specific histocompatibility antigen (HL-A B27) is documented by follow-up study of an epidemic of post-Shigella Reiter's syndrome. Five of the original 10 patients have been traced, HL-A typed, and clinically assessed 13 years after the initial episode. One of the 5 has minimal disease, remains symptom-free, and is HL-A B27-negative. The remaining 4 have followed a chronic course, have persistent active disease, and are HL-A B27-positive. It is estimated that after this single episode of shigellosis, from one sixth to one third of the persons who were HL-A B27-positive developed Reiter's syndrome. The prognosis for postdysenteric Reiter's syndrome must be guarded, especially in the subject who is B27-positive.
ANDREI CALIN, JAMES F. FRIES. An "Experimental" Epidemic of Reiter's Syndrome Revisited: Follow-up Evidence on Genetic and Environmental Factors. Ann Intern Med. 1976;84:564–566. doi: 10.7326/0003-4819-84-5-564
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Published: Ann Intern Med. 1976;84(5):564-566.
Infectious Disease, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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