JOHN W. ROWE, M.D.; REUBIN ANDRES, M.D.; JORDAN D. TOBIN, M.D.; ARTHUR H. NORRIS, M.S.; NATHAN W. SHOCK, PH.D.
Glomerular filtration rate (GFR) has been shown to decline with age after maturity (1). Creatinine clearance finds frequent use as a clinical estimate of GFR, and published criteria for severity of renal disease include classification of patients according to their creatinine clearance as compared with the "predicted normal" (2). In spite of this recommendation, no satisfactory age-adjusted normal standards for creatinine clearance are currently available. The present study was done in order to provide such standards.
Standard 24-h creatinine clearance measurements were done on 884 adult male subjects (17 to 96 years) in the Baltimore Longitudinal Study of Aging (3).
ROWE JW, ANDRES R, TOBIN JD, NORRIS AH, SHOCK NW. Age-Adjusted Standards for Creatinine Clearance. Ann Intern Med. ;84:567–569. doi: 10.7326/0003-4819-84-5-567
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Published: Ann Intern Med. 1976;84(5):567-569.
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