HOWARD SCHER, M.D.; ROBERT SILBER, M.D.
Recent experimental and clinical studies have provided evidence that iron has a role in the regulation of thrombopoiesis (1). Gross, Keffer, and Newman (2), studying 60 iron-deficient infants, noted the occurrence of thrombocytopenia and thrombocytosis. Both groups responded with a rise in platelet count, independent of hemoglobin level, after iron therapy. With further administration of iron, the platelet count stabilized at a normal level. In 1974, two cases have been reported that describe iron deficiency and thrombocytopenia corrected by parenteral iron administration (3, 4). Recently, we had the opportunity to study a polycythemic patient whose platelet count appeared sensitive to
SCHER H, SILBER R. Iron Responsive Thrombocytopenia. Ann Intern Med. ;84:571–572. doi: 10.7326/0003-4819-84-5-571
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Published: Ann Intern Med. 1976;84(5):571-572.
Hematology/Oncology, Platelet Disorders.
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