A. FEFER, M.D.; H. FREEMAN, M.D.; R. STORB, M.D.; J. HILL, M.D.; J. SINGER, M.D.; A. EDWARDS, M.D., F.A.C.P.; E. THOMAS, M.D.
An 18-year-old white Canadian male patient with paroxysmal nocturnal hemoglobinuria and refractory marrow failure received a marrow infusion from his normal identical twin brother without prior ablation of the patient's marrow by drugs or irradiation. After 2 years of follow-up, the patient is well with no evidence of clinical disease or significant hematological abnormality. The results suggest that normal marrow stem cells can have a selective advantage over the abnormal paroxysmal nocturnal hemoglobinuria clone.
FEFER A, FREEMAN H, STORB R, HILL J, SINGER J, EDWARDS A, et al. Paroxysmal Nocturnal Hemoglobinuria and Marrow Failure Treated by Infusion of Marrow from an Identical Twin. Ann Intern Med. ;84:692–695. doi: 10.7326/0003-4819-84-6-692
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Published: Ann Intern Med. 1976;84(6):692-695.
Hematology/Oncology, Red Cell Disorders.
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