SEWA LEGHA, M.D.; FRANCO M. MUGGIA, M.D., F.A.C.P.
To the editor: A recent editorial (Ann Intern Med 83: 730-731, 1975) commented on the usefulness of antiestrogens in the treatment of breast cancer. Antiestrogens such as nafoxidine and tamoxifen, as well as clomiphene, have been reported to induce objective clinical remissions in patients with this disease. In addition, they may have potential usefulness for the treatment of other neoplasms. Review of data in the Investigational Drug Branch of the National Cancer Institute indicates activity of these agents in renal, endometrial, and prostate cancer.
In a trial of nafoxidine in 20 patients with adenocarcinoma of the kidney, two complete and
LEGHA S, MUGGIA FM. Antiestrogens in the Treatment of Cancer. Ann Intern Med. ;84:751. doi: 10.7326/0003-4819-84-6-751_1
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Published: Ann Intern Med. 1976;84(6):751.
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