JOHN W. LITTLE, M.D.; WILLIAM J. HALL, M.D., F.A.C.P.; R. GORDON DOUGLAS Jr, M.D., F.A.C.P.; RICHARD W. HYDE, M.D.; DONNA M. SPEERS, B.S.
Amantadine HCl administration has resulted in accelerated resolution of influenza A illness. Prolonged abnormalities in pulmonary function have been described in uncomplicated influenza A. To study the effect of amantadine on these changes, we evaluated young adults with documented natural influenza A with clear chest examinations and X rays. Subjects received placebo or amantadine in random, doubleblind fashion. Physiologic studies included maximal expiratory flow volume curves with air and helium-oxygen mixtures. Air flow rates were unchanged in all subjects throughout. Initially, both groups showed comparable decreases in mean helium-oxygen maximal expiratory flow rates. The amantadine group showed accelerated physiologic improvement: significant increase in helium-oxygen flow rates occurred within 7 days (P < 0.05). The rate of improvement in the helium-oxygen flow rates in the placebo group was not statistically significant. These studies confirm peripheral airways dysfunction after uncomplicated influenza A and suggest that amantadine is associated with accelerated resolution of this dysfunction.
JOHN W. LITTLE, WILLIAM J. HALL, R. GORDON DOUGLAS, RICHARD W. HYDE, DONNA M. SPEERS. Amantadine Effect on Peripheral Airways Abnormalities in Influenza: A Study in 15 Students with Natural Influenza A Infection. Ann Intern Med. 1976;85:177–182. doi: 10.7326/0003-4819-85-2-177
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Published: Ann Intern Med. 1976;85(2):177-182.
Infectious Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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