GRANT E. DEGER, M.D.
Aflatoxins are toxic mold metabolites of Aspergillus flavus, a common and widely distributed food spoilage fungus. Aflatoxins have been identified in grains, coconuts, maze, oil seeds, and peanut meal. Humans ingesting stored moldy grain and nuts contaminated with aflatoxins characteristically develop liver damage: cholestasis, necrosis, bile duct proliferation, and even hepatomas (1). Furthermore, animals fed aflatoxins develop malignant neoplasms of multiple diverse organs including the colon (2). Aflatoxins apparently bind with DNA and translate this affinity into subsequently altered RNA and messenger protein (3).
Colon carcinoma developed in two men who had worked with purified aflatoxin. While a cause and
GRANT E. DEGER. Aflatoxin—Human Colon Carcinogenesis?. Ann Intern Med. 1976;85:204–205. doi: 10.7326/0003-4819-85-2-204
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Published: Ann Intern Med. 1976;85(2):204-205.
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