SUSANNE ULLMAN, M.D.; RICHARD L. SPIELVOGEL, M.D.; JOHN H. KERSEY, M.D.; ROBERT W. GOLTZ, M.D.
Graft-versus-host disease is a frequent complication after bone marrow transplantation. In this entity, histoincompatible donor lymphocytes may become aggressive and produce cellular damage responsible for the classic findings of disturbances of the skin, hepatocellular, and gastrointestinal tissue (1-3). Graft-versus-host disease may be either acute or chronic. Skin lesions that develop in patients undergoing bone marrow transplantation may be caused by cell-mediated mechanism. However, humoral antibodies may also be of pathogenetic importance (4). The skin lesions are often difficult to distinguish histopathologically from other skin conditions. Patients frequently receive high-dose chemotherapy and radiotherapy and multiple, potentially sensitizing drugs including antibiotics, and
ULLMAN S, SPIELVOGEL RL, KERSEY JH, GOLTZ RW. Immunoglobulins and Complement in Skin in Graft-Versus-Host Disease. Ann Intern Med. ;85:205. doi: 10.7326/0003-4819-85-2-205_1
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Published: Ann Intern Med. 1976;85(2):205.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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