ROBERT A. GREENWALD, M.D.
To the editor: Goldstein and colleagues (Ann Intern Med 84:445-446, 1976) have shown elevated lysozyme levels in sera from patients with hypercalcemia due to either hyperparathyroidism or malignancy, and they have interpreted their data in terms of the calcium-induced release of lysozyme from polymorphonuclear leukocytes (1). In the absence of direct measurements of intracellular, or releasable lysozyme levels, or both in polymorphonuclear leukocytes from the affected patients, this conclusion is premature, and an alternative explanation of their findings should be considered.
Lysozyme is a prominent component of many connective tissues, including bone (see Reference 2 for a detailed review), and
GREENWALD RA. Lysozyme and Calcium. Ann Intern Med. ;85:261. doi: 10.7326/0003-4819-85-2-261_1
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Published: Ann Intern Med. 1976;85(2):261.
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