ANDRÉ DE TROYER, M.D.; WILLY PILLOY, M.D.; IVO BROECKAERT, M.D.; JEAN-CLAUDE DEMANET, M.D., PH.D.
The role of antidiuretic hormone (ADH) in the pathogenesis of fluid retention in cirrhosis of the liver remains unclear. The defect in water excretion in these patients probably represents defective formation of free water rather than its excessive reabsorption. Nevertheless recent measurement of plasma vasopressin levels with a highly sensitive radioimmunoassay revealed high or normal values in ascitic patients, even when hyponatremia was present (1). This suggests that ADH may be responsible, at least in part, for the abnormal water retention in patients with cirrhosis.
We report here the first study of the effect in such patients of demeclocycline, a tetracycline
DE TROYER A, PILLOY W, BROECKAERT I, DEMANET J. Demeclocycline Treatment of Water Retention in Cirrhosis. Ann Intern Med. ;85:336. doi: 10.7326/0003-4819-85-3-336
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Published: Ann Intern Med. 1976;85(3):336.
Gastroenterology/Hepatology, Liver Disease.
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