ALLAN R. COOKE, M.D., F.A.C.P.
Although the gastric potential difference has been known since 1834, Swyngedauw in 1928 was probably the first to record it in man. Since then it has been studied by many investigators.
Measurement of transmucosal potential difference is safe and easy. An exploring and a reference electrode are made using polyethylene catheters filled with a saturated KCl-3% agar solution. The exploring electrode is placed near the surface of the mucosal layer using conventional intubation methods. The reference electrode, in vivo, is placed subcutaneously or in a peripheral vein, since there is no significant electropotential difference between the serosal surface and the
COOKE AR. Aspirin and the Transmucosal Potential Difference. Ann Intern Med. ;85:386–387. doi: 10.7326/0003-4819-85-3-386
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Published: Ann Intern Med. 1976;85(3):386-387.
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