THOMAS MOULDING, M.D., F.A.C.P.; MICHAEL ISEMAN, M.D., F.A.C.P.; JOHN SBARBARO, M.D., F.C.C.P.
To the editor: The NIH Conference on isoniazid liver injury in the February issue (Ann Intern Med 84:181-192, 1976) presented an interesting observation that might be used to prevent isoniazid hepatotoxicity in humans. Specifically, it was noted that when a single dose of 300 mg/kg of isoniazid was given to rats, no hepatotoxicity occurred despite pretreatment with phenobarbital. By contrast, when 100 mg/kg was given every hour for six doses, diffuse single cell necrosis of the liver occurred. The lack of toxicity with a single dose of isoniazid was stated to be due to saturation of the enzyme acetyltransferase, so
MOULDING T, ISEMAN M, SBARBARO J. Preventing Isoniazid Hepatotoxicity. Ann Intern Med. ;85:398–399. doi: 10.7326/0003-4819-85-3-398_2
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Published: Ann Intern Med. 1976;85(3):398-399.
Emergency Medicine, Gastroenterology/Hepatology, Liver Disease.
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