KAI-YIU YEUNG, M.D., F.A.C.P.; ARTHUR A. TROWBRIDGE, M.D.
To the editor: Mir and associates (1) noted the presence of hypokalemia (serum K, < 3.5 meq/litre) at some stage of the disease in 59% of 32 consecutive cases of acute myeloid leukemia and its variants. However, this abnormality has not been reported in chronic granulocytic leukemia. Recently, we have observed two patients with chronic granulocytic leukemia who developed hypokalemia during the acute blastic crisis. Their clinical features and laboratory data are summarized in Table 1.
The mechanism of the hypokalemia associated with acute myeloid leukemia and its variants has not been fully elucidated. By balance studies, Muggia and co-workers
YEUNG K, TROWBRIDGE AA. Chronic Granulocytic Leukemia: Hypokalemia in Acute Blastic Crisis. Ann Intern Med. ;85:533–534. doi: 10.7326/0003-4819-85-4-533
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Published: Ann Intern Med. 1976;85(4):533-534.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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