REUBIN EISENSTEIN, M.D.; KLAUS E. KUETTNER, PH.D.
To the editor: In a recent letter to this journal, Goldstein and colleagues (1) reported the occurrence of elevated serum lysozyme activity in hypercalcemic patients. Because increased serum lysozyme activity has previously been described in animals injected with either parathyroid extract (2) or vitamin D (3), and because we have encountered a similar phenomenon in man, we welcome this documentation in the literature.
On the basis of experimental studies, the authors suggest that this may be due to the selective release of lysozyme from leukocytes caused by elevated concentrations of ionized calcium. This hypothesis is both reasonable and well founded.
EISENSTEIN R, KUETTNER KE. Lysozyme from Bone?. Ann Intern Med. ;85:537–538. doi: 10.7326/0003-4819-85-4-537_3
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Published: Ann Intern Med. 1976;85(4):537-538.
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