BOBB G. CUCHER, M.D.; A. L. GOLDMAN, M.D.
D-penicillamine is an effective treatment for active rheumatoid arthritis (1). As more experience is gained with this drug, the more apparent becomes its spectrum of toxicity. A lupus-like syndrome (2) and polymyositis (3) have been reported as complications of D-penicillamine therapy. This report describes a patient who, 1 month after beginning therapy for rheumatoid arthritis, manifested signs and symptoms of polymyositis associated with myocarditis, proteinuria, and hypocomplementemia.
A 58-year-old woman was admitted to Columbia Hospital in Milwaukee, Wisconsin, 12 May 1975, for weakness. She had been in good health until 2½ years before admission when she was diagnosed as having
CUCHER BG, GOLDMAN AL. D-Penicillamine-Induced Polymyositis in Rheumatoid Arthritis. Ann Intern Med. ;85:615–616. doi: 10.7326/0003-4819-85-5-615
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Published: Ann Intern Med. 1976;85(5):615-616.
Neurology, Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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