JOHN R. HASERICK, M.D., F.A.C.P.
To the editor: I am in agreement with Dr. Barnett (Ann Intern Med 84:610, 1976) in contradicting "the pessimistic impression placed on combination therapy" in lupus erythematosus. Immunosuppressive therapy in acute lupus erythematosus is impossible to use alone because its therapeutic efficacy is simply too delayed to be practical. In short, the patient is dead before the beneficial effect of this drug group could possibly be noticed. Thus, polypharmacy must be practiced, objectionable as it is.
In our experience in treating lupus nephritis at the Cleveland Clinic, we learned quickly that nitrogen mustard, the drug we were interested in testing,
HASERICK JR. Therapy in Lupus Erythematosus. Ann Intern Med. ;85:681. doi: 10.7326/0003-4819-85-5-681_1
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Published: Ann Intern Med. 1976;85(5):681.
Lupus Erythematosus, Rheumatology.
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