MARTIN JEFFREY FRANK, M.D.
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To the editor: The recent paper by Goldschlager, Selzer, and Cohn, "Treadmill Stress Tests as Indicators of Presence and Severity of Coronary Artery Disease" (Ann Intern Med 85:277-286, 1976), provides much worthwhile information. However, the method for calculating specificity is disturbing. In the total of 141 "true negative" patients, there are 80 "healthy male volunteers" who did not undergo coronary arteriography. How can these patients be "truly negative" without angiographic confirmation? If these patients are not used for calculation of specificity, the figures of 93% (flat downsloping ST segments) and 82% (slowly upsloping ST segments included) will be significantly lower.
FRANK MJ. Specificity of Treadmill Stress Test. Ann Intern Med. ;85:826. doi: 10.7326/0003-4819-85-6-826_1
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Published: Ann Intern Med. 1976;85(6):826.
Cardiac Diagnosis and Imaging, Cardiology, Pulmonary/Critical Care.
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