CHARLES Y. C. PAK, M.D.; JUDITH TOWNSEND, R.N.
To the editor: In 1974 Palmer, Nelson, and Bacchus (1) reported that the ratio of serum chloride to phosphorus (Cl/P) was significantly higher in patients with primary hyperparathyroidism than in those with hypercalcemia from other causes. This observation has been
confirmed subsequently (2, 3). The higher value of Cl/P was attributed to the stimulation of renal bicarbonate and phosphate loss by parathyroid hormone. Recently Drago and associates (3) suggested that serum Cl/P might be useful, not only in the differentiation of primary hyperparathyroidism from other causes of hypercalcemia, but also in the diagnosis of primary hyperparathyroidism itself. It was implied
PAK CYC, TOWNSEND J. Chloride/Phosphorus in Primary Hyperparathyroidism. Ann Intern Med. ;85:830. doi: 10.7326/0003-4819-85-6-830
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Published: Ann Intern Med. 1976;85(6):830.
Endocrine and Metabolism, Parathyroid Disorders.
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