RICHARD D. SWARTZ, M.D.; JAMES E. RUBIN, M.D.; ROBERT S. BROWN, M.D., F.A.C.P.; HENRY M. YAGER, M.D.; THEODORE I. STEINMAN, M.D., F.A.C.P.; HOWARD S. FRAZIER, M.D.
Three postoperative patients with oliguric renal failure and hypochloremic metabolic alkalosis were treated with hemodialysis using a specially prepared high-chloride, low-acetate dialysate. This mode of therapy corrected the metabolic abnormalities and was significantly more effective than treatment with commercially available high-acetate dialysate at increasing the serum chloride and hydrogen ion concentration and decreasing the serum bicarbonate concentration. Furthermore, hemodialysis with high-chloride, low-acetate dialysate corrected the clinical sequelae of hypoventilation, cardiac arrhythmia, and neuromuscular irritability associated with metabolic alkalosis while treating uremia simultaneously.
SWARTZ RD, RUBIN JE, BROWN RS, YAGER HM, STEINMAN TI, FRAZIER HS. Correction of Postoperative Metabolic Alkalosis and Renal Failure by Hemodialysis. Ann Intern Med. 1977;86:52–55. doi: 10.7326/0003-4819-86-1-52
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Published: Ann Intern Med. 1977;86(1):52-55.
Nephrology, Renal Replacement Therapy.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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