JOSEPH M. CONNORS, M.D.
To the editor: To prepare for a recent housestaff conference I had to review the subject of insulin therapy in the treatment of diabetic ketoacidosis. I am concerned that the comparison between high-dose bolus insulin and low-dose intramuscular insulin made by Kitabchi and associates (1) does not justify their conclusion that "low dose intramuscular insulin therapy is simple and as effective as high dose therapy in the treatment of diabetic ketoacidosis without the risk of hypoglycemia and with a diminished incidence of hypokalemia."
The data presented by the authors showed that there was no significant difference between the two regimens
CONNORS JM. Insulin Therapy in Diabetic Ketoacidosis. Ann Intern Med. 1977;86:109–111. doi: 10.7326/0003-4819-86-1-109_2
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Published: Ann Intern Med. 1977;86(1):109-111.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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