JAMES A. O'CONNOR, M.D., F.A.C.P., F.A.I.C.
To the editor: In a recent editorial by Stauffer and Hill (1), "Systemic Contraceptives and Liver Tumors," we find repeated again a common misstatement that "both the synthetic estrogens and progesterones used in many of the oral contraceptive preparations are 17α-alkyl-substituted steroids" [italics added]. The facts are that no synthetic estrogen used in any contraceptive ever sold in United States and no synthetic progestogen used currently or during the past many years is a 17α-alkyl-substituted steroid.
The editorial then goes on to enumerate many hepatotoxic effects reported as due to synthetic estrogens and progestogens, two classes of hormones that are
O'CONNOR JA. Hepatotoxicity and the Oral Contraceptives. Ann Intern Med. ;86:118–119. doi: 10.7326/0003-4819-86-1-118_2
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Published: Ann Intern Med. 1977;86(1):118-119.
Emergency Medicine, Gastroenterology/Hepatology, Liver Disease.
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