GEORGE F. LONGSTRETH, M.D.; JUAN-R. MALAGELADA, M.D.; KEITH A. KELLY, M.D.
Patients with diabetes mellitus are occasionally afflicted by a syndrome of episodic nausea, vomiting, and gastric retention of food generally designated as diabetic gastroparesis (1). Its pathogenesis remains unkown, although autonomic parasympathetic neuropathy may have an important role. Conventional antiemetic therapy is often ineffective, and gastric surgery to promote drainage has failed to produce long-lasting relief. Metoclopramide, a compound structurally related to procainamide, which enhances gastric emptying, may be clinically useful in this condition (1, 2). We have quantified its effects on gastric motility and emptying of an ordinary, solid-liquid meal in a young diabetic patient with severe gastroparesis.
GEORGE F. LONGSTRETH, JUAN-R. MALAGELADA, KEITH A. KELLY. Metoclopramide Stimulation of Gastric Motility and Emptying in Diabetic Gastroparesis. Ann Intern Med. 1977;86:195–196. doi: 10.7326/0003-4819-86-2-195
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Published: Ann Intern Med. 1977;86(2):195-196.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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