DAVID R. GELBART, M.D.; ARVIN B. WEINSTEIN, M.D., F.A.C.P.; LUIS F. FAJARDO, M.D.
Four previous reports implicate allopurinol as a cause of acute renal failure in six patients (1-4). However, the renal histology in three autopsied patients was so variable that the existence of a specific allopurinol-induced renal disease has remained doubtful.
We describe a patient who developed dermatitis, eosinophilia and acute renal failure after 1 month's exposure to allopurinol. Renal biopsy, obtained during the early phase of acute renal failure, demonstrated acute interstitial nephritis.
After a 10-year history of schizophrenia and alcoholism this 53-year old black man presented in July 1975 with diastolic hypertension (160/100 mm Hg). Propanolol, 40 mg three times
GELBART DR, WEINSTEIN AB, FAJARDO LF. Allopurinol-Induced Interstitial Nephritis. Ann Intern Med. ;86:196–198. doi: 10.7326/0003-4819-86-2-196
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Published: Ann Intern Med. 1977;86(2):196-198.
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