DIETER W. GUMP, M.D., F.A.C.P.
To the editor: The paper by Hull and Sarubbi in the August 1976 issue (Ann Intern Med 85:183-189) has been useful in helping us to administer appropriate doses of gentamicin to our patients. The authors state that it is important that the dosage is based on lean body weight rather than total body weight because, as the authors point out, lean weight is a more accurate reflection of the volume distribution of the drug. Thus, if dosage is based on lean rather than total body weight, drug levels in obese patients will not be too high. The problem, however, is
GUMP DW. Gentamicin Dosage and Lean Body Mass. Ann Intern Med. ;86:239. doi: 10.7326/0003-4819-86-2-239_1
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Published: Ann Intern Med. 1977;86(2):239.
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