ED CADMAN, M.D.; J. R. BERTINO, M.D.
To the editor: At Yale we have treated 30 patients who had stage III or IV diffuse histiocytic lymphoma with a combination of cyclophosphamide, 1.5 g/m2 intravenously on Day 1; vincristine, 2 mg intravenously weekly X 3; followed by methotrexate (MTX), 80 to 120 mg/m2 intravenously weekly X 8 with leucovorin rescue beginning at 24 h; and cytosine arabinoside (cytarabine), 300 mg/m2 intravenously with each MTX dose (COMA). In a few patients the MTX-cytosine arabinoside was given for 3 weeks only. The sequence was repeated three or more times for a total treatment period of 9 months. The median survival
CADMAN E, BERTINO JR. Diffuse Histiocytic Lymphoma. Ann Intern Med. ;86:244–245. doi: 10.7326/0003-4819-86-2-244
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Published: Ann Intern Med. 1977;86(2):244-245.
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