JOHN L. ZIEGLER, M.D.; IAN T. MAGRATH, M.B., M.R.C.P.; PAUL GERBER, Ph.D.; PAUL H. LEVINE, M.D.
The association of the Epstein-Barr virus and two human malignancies, Burkitt's lymphoma and nasopharyngeal carcinoma, is reviewed. Seroepidemiologic, virologic, and immunologic evidence is summarized, and several hypotheses regarding a possible etiologic role for the Epstein-Barr virus in these tumors are presented. With our current state of knowledge we cannot conclude that the Epstein-Barr virus is oncogenic in man, nor can we yet ascertain the biological and clinical significance of its association with Burkitt's lymphoma and nasopharyngeal carcinoma.
ZIEGLER JL, MAGRATH IT, GERBER P, LEVINE PH. Epstein-Barr Virus and Human Malignancy. Ann Intern Med. 1977;86:323–336. doi: 10.7326/0003-4819-86-3-323
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Published: Ann Intern Med. 1977;86(3):323-336.
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