RICHARD M. HANSEN, M.D.
To the editor: The recent article by Dr. Logue (1) showing elevated levels of neutrophil-bound immunoglobulin G (IgG) in Felty's Syndrome is interesting, but his conclusion that "quantitation of granulocyte-bound IgG appears to be useful in defining patients with immunologically mediated granulocytopenia" is ill founded. The patient he described did have lessening of his granulocytebound IgG postsplenectomy but he remained significantly neutropenic in spite of it. Therefore, attributing a cause and effect relation between neutropenia and granulocytebound IgG is inappropriate.
The author admits that the membrane-bound IgG does not prove granulocyte antigen specificity and speculates that this could rather be
HANSEN RM. Granulocytes in Felty's Syndrome. Ann Intern Med. ;86:362–363. doi: 10.7326/0003-4819-86-3-362_2
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Published: Ann Intern Med. 1977;86(3):362-363.
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