KURT A. OSTER, M.D.
To the editor: In the September 1976 issue (Ann Intern Med 85:333-335), Lockard and associates state, "....there is a need for the development of additional xanthine oxidase inhibitors...."
This problem could have been solved as early as 1948, when Kalckar and Klenow (1) wrote:
"Effect of Pteroylglutamic Acid on Xanthopterin and Xanthine Oxidase—Milk xanthopterin oxidase is strongly inhibited by the addition of minute amounts of synthetic pteroylglutamic acid (PGA). Thus, in a sample containing oxidase and xanthopterin (0.06 micromole per ml.) the rate of oxidation was reduced to less than 5 per cent of the original activity by the presence
OSTER KA. Folic Acid and Xanthine Oxidase. Ann Intern Med. ;86:367. doi: 10.7326/0003-4819-86-3-367
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Published: Ann Intern Med. 1977;86(3):367.
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