JOSEPH A. FRANCIOSA, M.D., F.A.C.P.; GORDON PIERPONT, M.D., Ph.D.; JAY N. COHN, M.D., F.A.C.P.
Hydralazine was administered in a single oral dose of 50 to 100 mg in 16 patients with left ventricular failure due to cardiomyopathy. It produced sustained effects for at least 4 h characterized by a significant increase in cardiac output, a reduction in arterial and pulmonary arterial pressure, and a slight rise in heart rate. When compared to nitroprusside infusion in these same patients, hydralazine produced a similar reduction in systemic vascular resistance but a slightly greater increase in cardiac index (0.74 versus 0.95 litres/min · m2), with a lesser fall in mean arterial pressure (7.8 versus 13.6 mm Hg, P < 0.01), mean pulmonary arterial pressure (4.2 versus 11.3 mm Hg, P < 0.001), and pulmonary wedge pressure (5.5 versus 9.9 mm Hg, P < 0.001). Forearm venous tone decreased and venous compliance increased during nitroprusside infusion, but they were unchanged after hydralazine therapy. These data suggest that hydralazine may be a useful agent in the treatment of chronic left ventricular failure.
FRANCIOSA JA, PIERPONT G, COHN JN. Hemodynamic Improvement after Oral Hydralazine in Left Ventricular Failure: A Comparison with Nitroprusside Infusion in 16 Patients. Ann Intern Med. ;86:388–393. doi: 10.7326/0003-4819-86-4-388
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Published: Ann Intern Med. 1977;86(4):388-393.
Cardiology, Heart Failure.
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