WILLIAM J. JUSKO, Ph.D.; JEFFREY R. KOUP, Pharm.D.; JOHN W. VANCE, M.D.; JEROME J. SCHENTAG, Pharm.D.; PAUL KURITZKY, M.D.
We evolved a nomogram for guiding and standardizing intravenous theophylline therapy in hospitalized patients. It provides rapid calculation of a loading dose based on body weight and previous therapy and a maintenance infusion rate related to three categories of expected metabolic activity. The guidelines were prospectively used in the treatment of 72 patients, mainly in a respiratory care unit. The nomogram was successfully used to attain near-steady-state serum concentrations in the therapeutic range of 8 to 20 mg/litre in 72% of patients, with only two patients outside of the range of 5 to 25 mg/litre. These guidelines facilitate initial theophylline dosage in older patients with liver and cardiac disease and provide a rational basis for interpreting serum concentration measurements and adjustment of drug therapy.
JUSKO WJ, KOUP JR, VANCE JW, SCHENTAG JJ, KURITZKY P. Intravenous Theophylline Therapy: Nomogram Guidelines. Ann Intern Med. ;86:400–404. doi: 10.7326/0003-4819-86-4-400
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Published: Ann Intern Med. 1977;86(4):400-404.
Cardiology, Hospital Medicine.
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