CHARLES M. PETERSON, M.D., F.A.C.P.; ROBERT L. JONES, M.D.; RONALD J. KOENIG, B.S.; ELLEN T. MELVIN, M.D.; MARK L. LEHRMAN, M.D.
Seven patients with diabetes mellitus were hospitalized and their blood sugar concentrations regulated as a result of fasting blood sugar, sugar around meals, urinary sugar, and hemoglobin AIc assays. Erythrocyte half-life as measured by 51Cr increased in all patients from a mean of 27 days to 31 days, while hemoglobin AIc levels decreased from a mean of 10.1% to 5.6%. Leukocyte adherence increased in all patients from a mean of 28% to 51%. Most striking were the changes observed in platelet function in response to epinephrine. The length of the secondary lag phase of platelet aggregation, after a stimulus with final concentration of 70 µM of epinephrine, increased from a mean of 19 seconds to 65 seconds. Studies in additional patients confirmed an inverse correlation between hemoglobin AIc concentration and the secondary lag phase (r = 0.87, P < 0.001). These studies found that certain secondary sequelae of diabetes can be corrected by strict carbohydrate control and confirmed that hemoglobin AIc assays provide a useful means of showing the degree of control of glucose metabolism in diabetic patients.
PETERSON CM, JONES RL, KOENIG RJ, MELVIN ET, LEHRMAN ML. Reversible Hematologic Sequelae of Diabetes Mellitus. Ann Intern Med. ;86:425–429. doi: 10.7326/0003-4819-86-4-425
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Published: Ann Intern Med. 1977;86(4):425-429.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Hematology/Oncology.
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