ALLAN A. ORENSTEIN, M.D.; VINCENT YAKULIS, B.S.; JOSEPH EIPE, M.D.; NICOLAS COSTEA, M.D.
A number of adverse effects have been reported in association with hydralazine therapy including hyperdynamic circulation with increased heart rate and cardiac output, an acute rheumatoid state resembling disseminated lupus erythematosus, peripheral neuropathy, and various blood dyscrasias (1). Although a number of drugs have been shown to trigger immune hemolytic anemia (2, 3), hydralazine was not one of them; however, we have recently observed a patient who developed Coombs' positive hemolysis while receiving small doses of this drug for mild hypertension.
A 63-year-old white man was referred to us in July 1976 for evaluation of anemia. He was asymptomatic, without
ORENSTEIN AA, YAKULIS V, EIPE J, COSTEA N. Immune Hemolysis Due to Hydralazine. Ann Intern Med. ;86:450–451. doi: 10.7326/0003-4819-86-4-450
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Published: Ann Intern Med. 1977;86(4):450-451.
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